At a glance
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The SLIM Study: Sling and Botox® Injection for Mixed Urinary Incontinence
In Brief
A Phase 4 clinical trial evaluating OnabotulinumtoxinA (Botox ®) Injections and Saline Injections for Mixed Urinary Incontinence and 2 related conditions. Completed, enrolled 100 participants across 1 site.
Detailed Summary
This double-blind randomized controlled trial seeks to find a better treatment for women with mixed urinary incontinence (both stress and urgency incontinence). The primary aim is to determine whether midurethral sling surgery combined with injections of onabotulinumtoxinA (Botox®) into the detrusor muscle of the bladder improves symptoms of mixed urinary incontinence better than sling surgery alone.
Study Details
Timeline
Interventions
OnabotulinumtoxinA (Botox ®) is a neurotoxin, which inhibits acetylcholine release and temporarily relaxes the bladder muscle to inhibit urgency incontinence.
Saline will be injected into the bladder so that investigators are masked to subject randomization.