CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 905 enrolled
Drug / intervention
Dapagliflozin +3 moredrug
Likely dose
Dapagliflozin 5mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02681094
NCT02681094Phase 3Completed

A Multi-Center, Randomized, Double-Blind, Active-Controlled , Parallel Group, Phase III Trial to Evaluate the Safety and Efficacy of Saxagliptin 5mg Co-administered With Dapagliflozin 5mg Compared to Saxagliptin 5mg or Dapagliflozin 5mg All Given as Add-on Therapy to Metformin inPatients With Type 2 Diabetes Who Have Inadequate Glycaemic Control on Metformin Alone

AstraZeneca·interventional·Posted Feb 12, 2016·Updated Oct 10, 2018

In Brief

A Phase 3 clinical trial evaluating Dapagliflozin, Placebo for Dapagliflozin, and 2 other interventions for Type 2 Diabetes Mellitus and Inadequate Glycaemic Control. Completed, enrolled 905 participants across 110 sites in 6 countries.

Detailed Summary

The aim of this study is to evaluate safety and efficacy of therapy with saxagliptin 5mg co-administered with dapagliflozin 5mg, compared to therapy with saxagliptin 5mg or dapagliflozin 5mg in patients who are inadequately controlled on ≥1500mg/day of metformin monotherapy.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesCanada, Czechia, Germany, Mexico, Russia, United States
Collaborators--

Timeline

Phase 3CompletedFinished
20162017201820192020202120222023202420252026
First PostedFeb 12, 2016
Enrollment StartFeb 26, 2016
Primary CompletionJul 15, 2017
TodayJul 2, 2026
Enrollment to primary: 1.4 yearsPosted 10.4 years ago

Interventions

Dapagliflozindrug

5mg, orally, Green, plain, diamond-shaped, film-coated tablet

Placebo for Dapagliflozindrug

Does not contain active ingredient, orally, Green, plain, diamond-shaped, film-coated tablet

Saxagliptindrug

5mg, orally, Plain, yellow, biconvex, round, film-coated tablet

Placebo for Saxagliptindrug

Does not contain active ingredient, orally, Plain, yellow, biconvex, round, film-coated tablet