At a glance
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Effect of Wheat Bran Extract Containing Arabinoxylan Oligosaccharides, on the Gut Microbiota Composition and Well-being in Healthy Aging Subjects PhD Project: New Targeted Prebiotic Approaches for Maintaining Human Health
In Brief
A clinical study evaluating Placebo and Fibre supplement for Hypercholesterolemia and 2 related conditions. Completed, enrolled 21 participants across 1 site.
Detailed Summary
This is a placebo controlled, cross-over, randomized, double blinded study. The intervention food products will be taken as diet prebiotic supplements: 1. Wheat Bran Extract rich in arabinoxylan oligosaccharides : 15g/d (up to 10 g total additional dietary fibre per day). 2. Placebo product maltodextrin:equal amounts of a digestible carbohydrate. Primary endpoints are faecal microbiota analysis and faecal metabolite analysis (particularly, short chain fatty acid). Secondary endpoint is serum cholesterol, glucose, HDL and bowel function, gastrointestinal tolerance, quality of life and food frequency (by the use of questionnaires).
Study Details
Timeline
Interventions
15 g/day maltodextrin in 3 portions of 5 g.
15 g/day Wheat Bran Extract in 3 portions of 5 g.