At a glance
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Increased Lung Volume as Rescue Therapy for Asthma
In Brief
A Phase 2 clinical trial evaluating Positive Expiratory Pressure for Asthma. Completed, enrolled 18 participants across 1 site.
Detailed Summary
The purpose of this study is to test the effect of increasing lung volume with a simple hand-held device to both prevent, and also to relieve, airway constriction in people with asthma and a BMI ≥ 30 kg/m2. Twenty people with late onset non-allergic asthma and a BMI of ≥ 30 kg/m2 will be recruited. The efficacy of elevating lung volume on both preventing and reversing bronchoconstriction will be tested. Lung volume will be modulated by breathing out against a small level of resistance (positive expiratory pressure).
Study Details
Timeline
Interventions
Patient will exhale against positive expiratory pressure 0 mm or 10 mm while inhaling methacholine