At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Effect of Intravenously and Orally Administered Branched Chain Amino Acids on Incretin Response
In Brief
A clinical study evaluating IV BCAA, ORAL BCAA, and 1 other intervention for Glucose Metabolism Disorders. Completed, enrolled 18 participants across 1 site.
Detailed Summary
Branched chain amino acids (BCAA) are known to exert insulinogenic effect. Whether this effect is mediated by incretins (GLP-1, GIP) is not known. The aim of the study was to show incretin effect of BCAA, i.e. whether the oral administration of BCAA elicits higher insulin and incretin response when compared with IV route of the same dose of BCAA. Eighteen healthy, male subjects participated in three tests: IV application of BCAA solution (30.7±1.1 g of BCAA, IV BCAA) second was oral ingestion of BCAA capsules in the same dose (ORAL BCAA) and third experiment was oral placebo (PLACEBO). Glucose, insulin, GLP-1, GIP, valine, leucine and isoleucine levels were measured at time interval for up to 4 h.
Study Details
Timeline
Interventions
in total dose of 0,4 g/kg in a 2 h intravenous infusion
single dose of 0.4g/kg administered over 30s washed down with 500mL of tap water
single dose of 0.4 g/kg administered over 30 s washed down with 500mL of tap water