At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Analgetic Efficiency of Single-shot Perineural Low Dose Dexamethasone Added to Infraclavicular Block Anesthesia for Upper Limb Surgery
In Brief
A Phase 3 clinical trial evaluating Dexamethasone, Ropivacaine, and 3 other interventions for Postoperative Pain. Completed, enrolled 180 participants across 1 site.
Detailed Summary
Dexamethasone has an evidence-based indication in postoperative emesis prophylaxy and as a antiinflammatory steroid. Although the perineural administration is off-label, several studies recognised its analgetic action as an adjuvant for peripheral nerves blockade, permitting to reduce the concentration of the local anesthetics and extending the sensory and motor block.Questions remain concerning the mechanism of action, optimal dose, the lack/degree of toxicity and the comparison with intravenous administration.The aim of this prospective randomized controlled study is to investigate the efficacy of analgesia with 4 mg or 2 mg Dexamethasone added to a combination of ropivacaine 0,5% and lidocaine 1% in vertical infraclavicular blockade (VIB) anesthesia for upper limb surgery.
Study Details
Timeline
Interventions
One hour before surgery the patients received single shot VIB block with the mixture according to the group allocation
One hour before surgery the patients received single shot VIB block with the mixture according to the group allocation
After the block regression, at the first analgetic request the patients received the same analgesia protocol
After the block regression, at the first analgetic request the patients received the same analgesia protocol
One hour before surgery the patients received single shot VIB block with the mixture according to the group allocation