CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 1,671 enrolled
Drug / intervention
telmisartan 20mg, amlodipine 2.5mg, and indapamide 1.25mg +1 moredrug
Likely dose
telmisartan 20mg, amlodipine 2.5mg, and indapamide 1.25mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02699645
NCT02699645Phase 3Completed
CompareCT.gov

Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial (TRIDENT), Substudies: MRI, Cognitive

The George Institute·interventional·Posted Mar 4, 2016·Updated Sep 12, 2025

In Brief

A Phase 3 clinical trial evaluating telmisartan 20mg, amlodipine 2.5mg, and indapamide 1.25mg and Placebo for Intracerebral Haemorrhage (ICH) and Hypertension. Completed, enrolled 1,671 participants across 58 sites in 10 countries.

Detailed Summary

An investigator initiated and conducted, multicentre, international, double-blinded, placebo-controlled, parallel-group, randomised controlled trial to determine the effect of more intensive blood pressure control provided by a fixed low-dose combination blood pressure lowering pill ("Triple Pill") strategy on top of standard of care, on time to first occurrence of recurrent stroke in patients with a history of stroke due to intracerebral haemorrhage.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsIntracerebral Haemorrhage (ICH), Hypertension
CountriesAustralia, Brazil, Georgia, Malaysia, Netherlands, Nigeria, Singapore, Sri Lanka, Taiwan, United Kingdom
CollaboratorsThe University of New South Wales

Timeline

Phase 3CompletedFinished
20162017201820192020202120222023202420252026
First PostedMar 4, 2016
Enrollment StartSep 28, 2017
Primary CompletionAug 27, 2025
TodayJul 2, 2026
Enrollment to primary: 7.9 yearsPosted 10.3 years ago

Interventions

telmisartan 20mg, amlodipine 2.5mg, and indapamide 1.25mgdrug

1 pill taken orally once daily for average of 72 months

Placebodrug

1 pill taken orally once daily for average of 72 months