At a glance
ClinicalIndex Comparison Record- ✓Diagnosis of mild Alzheimer's disease per NINCDS-ADRDA criteria
- ✓Currently taking cholinesterase inhibitors
- ✓Sedentary lifestyle
- ✓Ability to do physical exercise
- ✕Parkinson disease
- ✕Down syndrome
- ✕Epilepsy or history of concussion
- ✕Drug or alcohol abuse
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Evaluating the Impact of Physical Exercise on Mild Alzheimer's Disease in a Randomized Clinical Trial: Quantification With 18F -FDG and 11C- AcAc PET Imaging
In Brief
A clinical study evaluating Physical exercise for Alzheimer's Disease. Completed, enrolled 15 participants across 1 site.
Detailed Summary
The aim of this study is to evaluate the effect of a 3-month walking program on brain energy metabolism in patient with mild Alzheimer's disease (AD). Two groups of sedentary patients with mild AD are followed and compared over a 3-month period of time: Control (non-active) and walking (from 15 to 45 minutes of exercise on a treadmill, 3 times a week for 12 weeks) groups. All the participants are evaluated on their cognition, brain volumes (MRI) and brain fuel consumption (PET scan with 18-FDG and 11C-AcAc) at the beginning and at the end of the study.
Study Details
Timeline
Interventions
A 3-month walking program (3 times a week for 12 weeks) on treadmill supervised by a physiotherapist. Duration of the exercise is progressively increased from 15 min to 45 min over a 6-week period and the intensity of the exercise is moderate (a 12-13 score on Borg scale).