CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 302 enrolled
Drug / intervention
Measles Vaccine at 9 months of age +2 morebiological
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02710045
NCT02710045N/ACompleted
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The Interaction Between Live and Killed Vaccines: the Effect of the Diphtheria-tetanus-whole Cell Pertussis (DTP) Combined Vaccine on T Cell Memory Following Measles Vaccination

Medical Research Council Unit, The Gambia·interventional·Posted Mar 16, 2016·Updated Jan 28, 2019

In Brief

A clinical study evaluating Measles Vaccine at 9 months of age, DTP Vaccine at 9 months of age, and 1 other intervention for Non-target Heterologous Effects of Vaccines and Vaccine Interactions. Completed, enrolled 302 participants.

Detailed Summary

The purpose of this study is to investigate for the broad immunological effects of administering measles vaccine (MV) and diphtheria-tetanus-whole cell pertussis vaccine (DTP) to 9 month old Gambian infants, either alone or together. Effects on vaccine-specific immune responses, innate immunity, and immune memory were studied. The hypothesis is that when MV and DTP are given together there will be more inflammation and this will interfere with generation of immunity to the vaccine and to other non-vaccine related stimuli.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsNon-target Heterologous Effects of Vaccines, Vaccine Interactions
Countries--
Collaborators--

Timeline

N/ACompletedFinished
20082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedMar 16, 2016
Enrollment StartNov 1, 2007
Primary CompletionMar 1, 2010
Study CompletionMay 1, 2011
TodayJul 2, 2026
Enrollment to primary: 2.3 yearsPosted 10.3 years ago

Interventions

Measles Vaccine at 9 months of agebiological

Single standard intramuscular (i.m.) dose of measles vaccine (MV) (Edmonston Zagreb strain, Serum Institute of India Ltd., Pune, India) into the deltoid at 9 months of age

DTP Vaccine at 9 months of agebiological

Single intramuscular (i.m.) dose of diphtheria-tetanus-whole cell pertussis vaccine (Serum Institute of India Ltd.) into the thigh at 9 months of age

Measles Vaccine at 18 months of agebiological

Single standard intramuscular (i.m.) dose of measles vaccine (MV) (Edmonston Zagreb strain, Serum Institute of India Ltd., Pune, India) into the deltoid at 18 months of age