At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Effect of Two Plasma Concentrations of Remifentanil Through Target Controlled Anesthesia on Frequency and Intensity of Coughing During Extubation: Randomized Controlled Clinical Trial
In Brief
A Phase 4 clinical trial evaluating Extubation U and Extubation T for Cough. Completed, enrolled 110 participants across 1 site.
Detailed Summary
Condition of the State: (terminated, recruiting, etc.) Terminated Study Design: Main Objective: Compare the frequency and intensity of coughing at the time of extubation with two infusions of remifentanil that predict a plasma concentration (PC) of 3 - 4 and 2 - 3 ng/ml, through the technique of target controlled anesthesia
Study Details
Timeline
Interventions
Dose of remifentanil according to the randomization; the infusions that were used to reach the PC target were: * 20 years old - 6.0 mcg/Kg/h * 30 years old - 5.7 mcg/Kg/h * 40 years old - 5.3 mcg/kg/h * 50 years old - 5.0 mcg/kg/h * 60 years old - 4.6 mcg/kg/h * 70 years old - 4.3 mcg/kg/h * 80 years old - 4.0 mcg kg/h.
Dose of infusion of remifentanil to reach a PC 3 - 4 ng/ml, in the following manner: The assistant placed the infusion balloon in such a way that it could not be seen by the treating anesthesiologist, he proceeded to open the corresponding wrapping according to the consecutive which corresponds to the patient. The remifentanil dose was adjusted according to the randomization: * 20 years old - 9.0 mcg/Kg/h * 30 years old - 8.5 mcg/Kg/h * 40 years old - 8.0 mcg/kg/h * 50 years old - 7.5 mcg/kg/h * 60 years old - 7.0 mcg/kg/h * 70 years old - 6.5 mcg/kg/h * 80 years old - 6.0 mcg kg/h.