CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 197 enrolled
Drug / intervention
Placebo +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02720523
NCT02720523Phase 3Completed

A Phase 2b/3, Randomized, Double-Blind Study Comparing Upadacitinib (ABT-494) to Placebo in Japanese Subjects With Moderately to Severely Active Rheumatoid Arthritis Who Are on a Stable Dose of Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs) and Have an Inadequate Response to csDMARDs

AbbVie·interventional·Posted Mar 28, 2016·Updated Jun 7, 2023

In Brief

A Phase 3 clinical trial evaluating Placebo and Upadacitinib for Rheumatoid Arthritis. Completed, enrolled 197 participants across 50 sites.

Detailed Summary

This is a randomized, double-blind study comparing ABT-494 to placebo in Japanese participants with moderately to severely active rheumatoid arthritis who are on a stable dose of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) and have an inadequate response. Following marketing approval of upadacitinib for rheumatoid arthritis in Japan, this study will become a post-marketing clinical study and include a long-term extension period.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesJapan
Collaborators--

Timeline

Phase 3CompletedFinished
20162017201820192020202120222023202420252026
First PostedMar 28, 2016
Enrollment StartMar 22, 2016
Primary CompletionAug 3, 2017
Study CompletionJun 7, 2022
TodayJul 2, 2026
Enrollment to primary: 1.4 yearsPosted 10.3 years ago

Interventions

Placebodrug

Tablet; Oral

Upadacitinibdrug

Tablet; Oral