At a glance
ClinicalIndex Comparison Record- ✓Undergoing epidural analgesia for perioperative pain management associated with major surgery
- ✓Undergoing major thoracic surgery
- ✓Undergoing major abdominal surgery
- ✓Undergoing major orthopaedic surgery
- ✕Sepsis
- ✕Acute trauma
- ✕Coagulopathy
- ✕Preoperative hemodynamic instability
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
The Prevention of Hypotension After Epidural Analgesia After Major Surgery by Adding Epinephrine to Infusions to Counteract Sympathectomy: a Double- Blind, Controlled, Randomized, Prospective Dose-finding Study
In Brief
A Phase 2 clinical trial evaluating Ropivacaine and Epinephrine for Hypotension and Pain. Completed, enrolled 66 participants across 1 site.
Detailed Summary
Epidural analgesia via continuous epidurally infused local anesthetic agent (LA) is widely and very successfully used routinely for perioperative pain control in patients undergoing major orthopedic and abdominal surgery since 1928. The choice currently depends on the preference of the APS physician in charge of the case. A frequent unwanted side effect of epidural block is hypotension due to the epidurally injected LA blocking the sympathetic nerves and thus the patient's response to hypotension, which is usually due to hypovolemia and/or an unopposed parasympathetic (via the vagus nerve) nervous system. The purpose of this research study is to see if adding epinephrine, to the epidural anesthetic will decrease possible side effects, such as low blood pressure, and lead to a better effect of the epidural anesthetic.
Study Details
Timeline
Interventions
Epidural block infusion with Ropivacaine 0.2% will be provided as the anesthesia per standard of care during the procedure.
Participants will receive epinephrine in their epidural block infusion during the procedure. The amount of epinephrine provided during the procedure will be based on the group assignment.