CI

At a glance

ClinicalIndex Comparison Record
N/AActive· 64 enrolled
Drug / intervention
active low-intensity transcranial electrical stimulation/active transcranial ultrasound +1 moredevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02723929
NCT02723929N/AActive
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Effects of Transcranial Direct Current Stimulation (tDCS) and Transcranial Ultrasound (TUS) on the Perception of Pain and Functional Limitations Due to Osteoarthritis of the Knee

Spaulding Rehabilitation Hospital·interventional·Posted Mar 31, 2016·Updated Sep 29, 2025

In Brief

A clinical study evaluating active low-intensity transcranial electrical stimulation/active transcranial ultrasound and Sham low-intensity transcranial electrical stimulation/sham transcranial ultrasound for Chronic Pain and Osteoarthritis. Active but no longer recruiting, targeting 64 participants across 1 site.

Detailed Summary

The purpose of this study is to investigate the effects of transcranial direct current stimulation (tDCS) in conjunction with transcranial ultrasound (TUS) on pain perception and functional limitations in people with osteoarthritis of the knee. The investigators hypothesize that there will be a decrease in pain levels with active stimulation, when compared to sham stimulation.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsChronic Pain, Osteoarthritis
CountriesUnited States
CollaboratorsHighland Instruments, Inc.

Timeline

N/AActive
201620172018201920202021202220232024202520262027
First PostedMar 31, 2016
Enrollment StartSep 1, 2016
Primary CompletionAug 15, 2019
Study CompletionDec 7, 2026
TodayJul 2, 2026
Enrollment to primary: 3.0 yearsPosted 10.3 years ago

Interventions

active low-intensity transcranial electrical stimulation/active transcranial ultrasounddevice

Subjects will undergo 20 minutes of low-intensity transcranial electrical stimulation of up to 2mA. During active stimulation, the current will be active for the full 20 minutes. Subjects will also undergo 20 minutes of transcranial ultrasound. During active stimulation, the ultrasound will be active for the full 20 minutes.

Sham low-intensity transcranial electrical stimulation/sham transcranial ultrasounddevice

Subjects will undergo 20 minutes of low-intensity transcranial electrical stimulation, as in the active condition; however, during sham stimulation (placebo) the current will not be active for the full 20 minutes. Subjects will also undergo 20 minutes of transcranial ultrasound in the same par. During active stimulation, the ultrasound will be active for 20 minutes - however, during sham stimulation (placebo) the ultrasound will not be active for the full 20 minutes.