At a glance
ClinicalIndex Comparison RecordPhase 4Completed· 130 enrolled
Drug / intervention
Dexamethasone +1 moredrug
Likely dose
Dexamethasone 8 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Manipulation Under Anesthesia (MUA) to Treat Postoperative Stiffness After Total Knee Arthroplasty: A Multicenter Randomized Clinical Trial
In Brief
A Phase 4 clinical trial evaluating Dexamethasone and Celecoxib for Stiffness Following Total Knee Arthroplasty. Completed, enrolled 130 participants across 16 sites.
Detailed Summary
Compare the outcome following manipulation under anesthesia for stiffness in a randomized controlled fashion with one group receiving IV dexamethasone and oral celecoxib at the time of manipulation to a control group receiving manipulation alone. Outcomes will include pain, range of motion, as well as subjective outcome scores.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
CollaboratorsKnee Society
Timeline
Phase 4CompletedFinished
20162017201820192020202120222023202420252026
Enrollment StartApr 2016
First PostedApr 2016
Primary CompletionDec 2022
TodayJul 2026
First PostedApr 14, 2016
Enrollment StartApr 1, 2016
Primary CompletionDec 1, 2022
TodayJul 2, 2026
Enrollment to primary: 6.7 yearsPosted 10.2 years ago
Interventions
Dexamethasonedrug
8 mg of IV dexamethasone immediately before MUA.
Celecoxibdrug
2 weeks per mouth of celecoxib (200 mg daily)