At a glance
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Efficacy of Preoperative Autologous Blood Donation and Tranexamic Acid in Revision Total Hip Arthroplasty: a Randomized Controlled Trial
In Brief
A Phase 4 clinical trial evaluating transfused pre-operatively donated autologous blood., intravenous tranexamic acid (TXA) infusion, and 1 other intervention for Revision Total Hip Arthroplasty (RTHA). Completed, enrolled 60 participants.
Detailed Summary
Sixty patients aged between 60 and 75 years old of both sex of ASA physical status I and II were included in this randomized study who were divided into the study group of 30 patients who had been transfused autologous blood and the control group of 30 patients who had been transfused only allogeneic blood. Parenteral iron preparation was given to all patients of the study group after each donation. Intraoperatively all patients of the study group received 2 grams of intravenous tranexamic acid. This study was conducted through the laboratory analysis of the hemoglobin and the hematocrit values during blood donation and for both groups in the pre-operative and the post-operative period and the assessment of the amount of transfused blood units in both groups.
Study Details
Timeline
Interventions
Pre-operative autologous donation for minimising perioperative allogeneic blood transfusion
Intravenous tranexamic acid is a safe pharmacological treatment to reduce blood loss and transfusion requirements in patients undergoing major orthopedic surgery.