CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 120 enrolled
Drug / intervention
Ketamine +1 moredrug
Likely dose
Ketamine 1 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02753114
NCT02753114Phase 4Completed

Prehospital Analgesia With Intra-Nasal Ketamine

University of British Columbia·interventional·Posted Apr 27, 2016·Updated Oct 22, 2018

In Brief

A Phase 4 clinical trial evaluating Ketamine and Normal Saline for Pain and Acute Pain. Completed, enrolled 120 participants across 1 site.

Detailed Summary

Acute painful conditions make-up a large proportion of pre-hospital transports in British Columbia (BC) yet Basic Life Support (BLS) paramedics have limited options to provide analgesia and therefore adequate and timely pain relief is often significantly delayed. Inhaled nitrous oxide is commonly used as a pre-hospital analgesic and is considered "usual care" for pre-hospital providers in BC, but its utility in severe pain is uncertain. Moreover, nitrous oxide is limited in its effectiveness by a short duration of action, nausea, vomiting, and the necessity for patient cooperation. IN Ketamine has been shown to provide rapid, easily-administered, and well-tolerated analgesia in many settings. The investigators believe that the addition of IN ketamine to usual care with nitrous oxide inhalation for adults experiencing moderate to severe intensity acute pain in the pre-hospital setting will result in improved pain severity, improved patient-reported comfort, and improved patient satisfaction.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPain, Acute Pain
CountriesCanada

Timeline

Phase 4CompletedFinished
2017201820192020202120222023202420252026
First PostedApr 27, 2016
Enrollment StartNov 6, 2017
Primary CompletionMay 24, 2018
TodayJul 2, 2026
Enrollment to primary: 7 monthsPosted 10.2 years ago

Interventions

Ketaminedrug

Intranasal Ketamine administered via mucosal atomization device at 0.5 - 1 mg / kg IN.

Normal Salinedrug

Intranasal Normal Saline administered via mucosal atomization device.