At a glance
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A Randomized Controlled Trial of Three Prophylactic Antibiotic Regimens for First Trimester Surgical Abortion
In Brief
A clinical study evaluating Azithromycin, Doxycycline, and 2 other interventions for First Trimester Abortion. Completed, enrolled 181 participants across 2 sites.
Detailed Summary
This study, a double blinded randomized controlled trial, is being done to compare side effects of commonly used antibiotic regimens prior to same day abortion procedures. In total, 180 pregnant women in their first trimester of pregnancy (5 0/6-13 6/7 weeks gestation) will be randomized to receive one of the three commonly used antibiotics (azithromycin, doxycycline, metronidazole) for same day abortion procedures or placebo prior to their abortion procedure. Approximately, 30-60 mins after study drug administration, the procedure will be performed. A sub-study will be completed on 40 women who consent to endometrial sampling and to have their blood drawn.
Study Details
Timeline
Interventions
500 mg
200 mg
500 mg
Placebo pills will be given before the uterine aspiration. Antibiotics will be given after the uterine aspiration.