At a glance
ClinicalIndex Comparison Record- ✓Aged between 18 and 80 years
- ✓Demonstrates understanding and willingness to participate with written informed consent
- ✓Able to accommodate lower bilateral buccal intra-oral appliances with four dentine samples
- ✓Good general and mental health with no clinically significant abnormalities in medical history or oral examination
- ✕Pregnant or intending to become pregnant during the study
- ✕Breast-feeding
- ✕Current or recurrent dental pathology that could affect study outcomes, including severe gingivitis, carious lesions, periodontal disease, or severe dental erosion
- ✕Known or suspected intolerance or hypersensitivity to study materials or their ingredients
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Assessment of Dentine Tubule Occlusion in a Modified in Situ Model
In Brief
A clinical study evaluating Stannous fluoride, Sodium monofluorophosphate, and 1 other intervention for Dentin Sensitivity. Completed, enrolled 26 participants across 1 site.
Detailed Summary
This will be a single centre, single blind, randomized, three treatment, three period crossover design, modified, in situ, study in healthy participants. In this in situ model the tubule occlusion properties of dentifrices will be evaluated by comparing an experimental dentifrice formulation to a regular fluoride dentifrice and a negative control (mineral water) over a ten day period.
Study Details
Timeline
Interventions
Dentifrice containing 0.454% stannous fluoride
Dentifrice containing 0.76% sodium monofluorophosphate
Commercially available mineral water