At a glance
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Anabolic Responsiveness to Protein Intake in Chronic Heart Failure and Chronic Obstructive Pulmonary Disorder
In Brief
A clinical study evaluating sip feeding with stable isotope infusion for Pulmonary Disease, Chronic Obstructive and Congestive Heart Failure. Completed, enrolled 90 participants across 1 site.
Detailed Summary
Weight loss commonly occurs in patients with chronic heart failure (CHF) and chronic obstructive pulmonary disorder (COPD), negatively influencing their quality of life, treatment response and survival. Loss of muscle protein is generally a central component of weight loss in CHF and COPD patients, but patients also have reductions in fat mass and bone density, independent of the severity of the disease state. The purpose of this study is to provide detailed insight in disease related gut function by obtaining information on gut permeability, digestion and absorption of glucose, fat and protein in CHF and COPD patients compared to matched healthy controls. This will provide required information that is necessary to implement new strategies to develop optimal nutritional regimen in CHF and COPD.
Study Details
Timeline
Interventions
such as glycerol, D2O, tyrosine, phenylalanine, glucose, arginine, and citrulline