CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 134 enrolled
Drug / intervention
Morphine +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02789410
NCT02789410N/ACompleted
CompareCT.gov

Intrathecal Morphine Versus Intrathecal Hydromorphone for Analgesia Following Cesarean Delivery

Mayo Clinic·interventional·Posted Jun 3, 2016·Updated Apr 25, 2019

In Brief

A clinical study evaluating Morphine and Hydromorphone for Analgesia, Obstetrical and Obstetric Surgical Procedures. Completed, enrolled 134 participants across 1 site.

Detailed Summary

Intrathecal (IT) opioids are commonly administered with local anesthetic during spinal anesthesia for post-Cesarean delivery analgesia. Traditionally, IT morphine has been used but the use of IT hydromorphone is growing. A previous study has shown that the effective dose for postoperative analgesia in 90% patients (ED90) for both IT hydromorphone and IT morphine (NCT02009722). These doses were found to be 75 mcg for hydromorphone and 150 mcg for morphine. The current proposed study would compare the duration of analgesia of IT morphine vs IT hydromorphone after elective cesarean delivery. Additionally, the investigators will compare each drug with respect the incidence of nausea and pruritus.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAnalgesia, Obstetrical, Obstetric Surgical Procedures
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
2017201820192020202120222023202420252026
First PostedJun 3, 2016
Enrollment StartMay 1, 2016
Primary CompletionSep 1, 2017
Study CompletionMar 15, 2018
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 10.1 years ago

Interventions

Morphinedrug

Morphine is administered as part of spinal anesthesia for post-operative pain relief.

Hydromorphonedrug

Hydromorphone is administered as part of spinal anesthesia for post-operative pain relief.