At a glance
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Physiologic Effects of Stress Dose Corticosteroids in the Management of Inhospital Cardiac Arrest - CORTICA
In Brief
A Phase 2 clinical trial evaluating Methylprednisolone; hydrocortisone and Saline Placebo for Inhospital Cardiac Arrest. Completed, enrolled 100 participants across 2 sites.
Detailed Summary
Early stress-dose steroids are of uncertain efficacy in cardiac arrest. The current authors plan to conduct a prospective, randomized, placebo controlled evaluation of stress-dose steroids efficacy with repect to early postresuscitation hemodynamics, heart function, brain perfusion, and inflammatory response in vasopressor-requiring cardiac arrest. Patients will also be followed for organ dysfunction, potential, steroid-associated complications, and functional outcome at hospital discharge.
Study Details
Timeline
Interventions
Methylprednisolone 40 mg during resuscitation and stress-dose hydrocortisone for postresuscitation shock
Saline placebo during resuscitation and during the postresuscitation phase.