At a glance
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Oral Dexamethasone for the Treatment of Acute Migraine Recurrence in Pediatric Patients Presenting to the Emergency Department With Migraine: A Pilot Randomized Controlled Trial
In Brief
A Phase 3 clinical trial evaluating Dexamethasone and Placebo for Migraine. Completed, enrolled 12 participants across 1 site.
Detailed Summary
Migraine recurrence is common amongst pediatric patients being discharged from the emergency department after treatment for migraine. Despite the commonality of migraine recurrence within the week following discharge, no known effective therapies are available in the pediatric population, though dexamethasone has been established as efficacious in the adult migraine population. The proposed study will randomly assign children and adolescents visiting the emergency department (ED) for migraine to receive either one dose of oral dexamethasone or oral placebo. Twenty patients will be recruited to this randomized, double-blind, pilot trial over a 6 month period, and the aim of the study will be to determine the feasibility and acceptability of the protocol.
Study Details
Timeline
Interventions
Dexamethasone 0.6mg/kg (maximum 15mg) PO x 1 dose
Matched oral solution