CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 180 enrolled
Drug / intervention
Adductor canal block +6 moredrug
Likely dose
Adductor canal block: 20 mL of 0.5% ropivacaine (single injection) or continuous 0.2% ropivacaine infusion via catheter, with or without 8 mg IV dexamethasone; plus spinal anesthesia with 2-3 mL of 0.5% bupivacaine and 0-20 mcg fentanyl; plus 30 mL of 0.5% ropivacaine peri-articular infiltrationAI-extracted
Key inclusion· 5
  • ✓Age ≥18 years and able to understand study protocol and give consent
  • ✓ASA classification 1-3
  • ✓Preoperative opioid consumption ≤30 mg morphine equivalents per 24 hours
  • ✓Ability to understand and use patient-controlled analgesia
Key exclusion· 9
  • ✕Contraindication to neuraxial and/or regional anesthesia
  • ✕Allergy to local anesthetics
  • ✕Chronic pain unrelated to knee joint
  • ✕Chronic opioid use (daily or almost daily for >3 months)

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02798835
NCT02798835Phase 4Completed
CompareCT.gov

Adductor Canal Block: Single Injection vs Catheter for Pain Management of Total Knee Arthroplasty - A Randomized, Unblinded, Non-Inferiority Trial

University of British Columbia·interventional·Posted Jun 14, 2016·Updated Sep 4, 2020

In Brief

A Phase 4 clinical trial evaluating Adductor canal block, Adductor canal block with dexamethasone, and 5 other interventions for Total Knee Arthroplasty. Completed, enrolled 180 participants.

Detailed Summary

This study investigates single injection adductor canal block (ACB) with or without intravenous dexamethasone and adductor canal catheter for pain management of total knee arthroplasty. This is a non-inferiority trial seeking to determine whether single injection ACB with dexamethasone is "no worse" than a continuous catheter.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsTotal Knee Arthroplasty
Countries--
Collaborators--

Timeline

Phase 4CompletedFinished
2017201820192020202120222023202420252026
First PostedJun 14, 2016
Enrollment StartJul 1, 2016
Primary CompletionDec 1, 2016
TodayJul 2, 2026
Enrollment to primary: 5 monthsPosted 10.0 years ago

Interventions

Adductor canal blockdrug

Spinal anesthesia with 2-3 ml 0.5% bupivacaine and 0-20mcg of fentanyl. At the end of the case, the surgeon will infiltrate 30ml 0.5% ropivacaine peri-articularly. 20ml 0.5% ropivacaine in the adductor canal in PACU.

Adductor canal block with dexamethasonedrug

Spinal anesthesia with 2-3 ml 0.5% bupivacaine and 0-20mcg of fentanyl. At the end of the case, the surgeon will infiltrate 30ml 0.5% ropivacaine peri-articularly. 20ml 0.5% ropivacaine in the adductor canal along with 8mg dexamethasone IV in PACU.

Adductor canal catheterdrug

Spinal anesthesia with 2-3 ml 0.5% bupivacaine and 0-20mcg of fentanyl. At the end of the case, the surgeon will infiltrate 30ml 0.5% ropivacaine peri-articularly. 20ml 0.5% ropivacaine and a catheter placed in PACU, with a continuous infusion of 0.2% ropivacaine started.

Bupivacainedrug

Used in spinal anesthetic

Fentanyldrug

May or may not be used in spinal anesthetic

Ropivacaine 0.5% Injectable Solutiondrug

Local anesthetic to be used by surgeon as local infiltration and by anesthesiologist in adductor canal block.

Dexamethasonedrug

To be given intravenously at time of nerve block to one of the study arms.