CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 20 enrolled
Drug / intervention
Subthreshold 577 nm yellow wavelength laser photo-coagulatorprocedure
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02800356
NCT02800356N/ACompleted
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Subthreshold Laser Treatment for Reticular Pseudodrusen and Incipient Geographic Atrophy Secondary to Age - Related Macular Degeneration: a Pilot Study

Ospedale San Raffaele·interventional·Posted Jun 15, 2016·Updated Mar 20, 2025

In Brief

A clinical study evaluating Subthreshold 577 nm yellow wavelength laser photo-coagulator for Age-Related Macular Degeneration and 2 related conditions. Completed, enrolled 20 participants across 1 site.

Detailed Summary

To evaluate the effectiveness of subthreshold laser treatment on retinal sensitivity in patients with reticular pseudodrusen and incipient Geographic Atrophy (GA) secondary to Age-Related Macular Degeneration (AMD). Secondary objective is to investigate changes in best-corrected visual acuity, atrophy progression and safety.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAge-Related Macular Degeneration, Geographic Atrophy, Reticular Pseudodrusen
CountriesItaly
Collaborators--

Timeline

N/ACompletedFinished
2017201820192020202120222023202420252026
First PostedJun 15, 2016
Enrollment StartJun 1, 2016
Primary CompletionSep 1, 2019
TodayJul 2, 2026
Enrollment to primary: 3.3 yearsPosted 10.0 years ago

Interventions

Subthreshold 577 nm yellow wavelength laser photo-coagulatorprocedure

Subthreshold photocoagulation is a method in which the burn spots (treated areas) cannot be seen with biomicroscopy, on color fundus photograph, on Optical Coherence Tomography or Fluorescein Angiography when the subthreshold level is adequately set. Subthreshold photocoagulation can be considered to be truly minimally invasive or non-damaging photocoagulation. A term sometimes used is photo-thermal stimulation since the Retinal Pigment Epithelium (RPE) layer is heated and stimulated, but not destroyed. The threshold level output power is set to obtain barely visible burn at approximately 200 mW to 250 mW using the titration mode, and irradiation is conducted after switching over to Endpoint Management.