At a glance
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The Effects of Electroconvulsive Therapy (ECT) and/or Intermittent Theta Burst Stimulation (iTBS) on Olfaction and Cognition in Patients With Depression
In Brief
An observational study evaluating Cognitive Function Imaging and Battery, Sniffin Sticks, and 1 other intervention for Depression. Completed, enrolled 30 participants.
Detailed Summary
The sense of smell and cognition are known to be closely associated with mood and emotional processes. However, despite the clear links between olfaction and cognitive processes with emotional states, research into the role of olfaction, cognition, and mood disorders has so far yielded variable results. This study proposes to investigate the ability to detect and identify odours and assess cognition in a group of patients with unipolar and bipolar depression prior to and after receiving their scheduled electroconvulsive therapy (ECT) or intermittent theta burst stimulation (iTBS) treatments. Olfaction will be evaluated utilizing standard olfactory testing protocols using commercially available kits. Cognition will be evaluated utilizing standard cognitive test protocols in a functional magnetic resonance imaging protocol. The results will potentially shed light on the link between olfaction, cognition and mood disorders.
Study Details
Timeline
Interventions
Individuals will be placed in the fMRI scanner and complete the NBACK Cognitive Task
Using Sniffin Sticks, olfactory functioning will be assessed using three tests: identification, discrimination, and threshold.
Participants will conduct the following cognitive batteries: DSST, TMT A \& B, RAVLT