CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 86 target
Drug / intervention
Remote Ischemic Preconditioningprocedure
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02808754
NCT02808754N/ACompleted
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Remote Ischemic Preconditioning for Carotid Endarterectomy

University of Pittsburgh·interventional·Posted Jun 22, 2016·Updated Feb 8, 2019

In Brief

A clinical study evaluating Remote Ischemic Preconditioning for Carotid Stenosis and Endarterectomy, Carotid. Completed, enrolled 86 participants across 1 site.

Detailed Summary

This is a randomized controlled trial designed to test an intervention (Remote ischemic preconditioning) in patients undergoing carotid endarterectomy (CEA) for carotid artery stenosis (CAS). The outcomes of interest include neurocognitive function, cardiac complications, and biomarkers of brain ischemia.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCarotid Stenosis, Endarterectomy, Carotid
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
2017201820192020202120222023202420252026
First PostedJun 22, 2016
Enrollment StartDec 1, 2016
Primary CompletionJan 1, 2019
TodayJul 2, 2026
Enrollment to primary: 2.1 yearsPosted 10.0 years ago

Interventions

Remote Ischemic Preconditioningprocedure

Those randomized to RIPC will undergo a standard protocol of 4 cycles of 5 minutes of forearm ischemia with 5 minutes of reperfusion requiring 35 minutes for an application. Forearm ischemia will be induced by a blood pressure cuff inflated to 200mmHg or at least 15mmHg higher than the systolic pressure if systolic \> 185mmHg or until the radial pulse is obliterated. This can occur during anesthesia induction and incision/dissection prior to manipulation or clamping of the carotid.