At a glance
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The Long-term Effect of Perineural Injection Therapy in Patients With Carpal Tunnel
In Brief
A clinical study evaluating Ultrasound-guided perineural injection with 5% dextrose, Ultrasound-guided perineural injection with normal saline, and 2 other interventions for Carpal Tunnel Syndrome. Completed, enrolled 60 participants across 1 site.
Detailed Summary
Carpal tunnel syndrome (CTS) is the most common peripheral entrapment neuropathy with involving compression of the median nerve in the carpal tunnel. Rather than other progressive disease, CTS is characterized by remission and recurrence. Although many conservative managements of CTS, the effectiveness of these methods is insignificant or only persist for a short duration. Recently, the ultrasound-guided perineural injection with 5% dextrose was widely used for entrapment neuropathy with positive benefit. However, current studies have not entirely proved the effects of perineural injection on peripheral neuropathy because these studies enrolled small number of patients and lacked controlled design. The investigators design a randomized, double-blind, controlled trail to assess the effect after ultrasound-guided perineural injection with 5% dextrose in patients with CTS.
Study Details
Timeline
Interventions
Ultrasound-guided perineural injection with 5% dextrose (3cc) between proximal carpal tunnel and surrounding median nerve with hydrodissection.
Ultrasound-guided perineural injection with normal saline (3cc) between proximal carpal tunnel and surrounding median nerve with hydrodissection.
Normal saline is safe for perineural injection.
5% Dextrose could decrease the release of CGRP and substance P to reduce the nerve inflamation.