At a glance
ClinicalIndex Comparison Record- ✓Age 70-85 years
- ✓BMI ≤35 kg/m²
- ✓High-functioning stratum: SPPB ≥11 (n=10 males, 10 females)
- ✓Low-functioning stratum: SPPB 4-7 (n=10 males, 10 females)
- ✕Acute or terminal illness
- ✕Surgery in past 6 months
- ✕Lower extremity fracture within past 6 months
- ✕Myocardial infarction in past 6 months
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Role of the Gut Microbiome and Serum Metabolome on Lean Mass and Physical Function in Older Adults
In Brief
An observational study for Sarcopenia. Completed, enrolled 29 participants across 1 site.
Detailed Summary
The investigators recently published significant associations between circulating gut bacteria-related metabolites with lean and skeletal muscle mass and with measures of physical function in older adults, evidence that suggests a role for gut bacteria on the maintenance of these outcomes. To date, studies aimed at identification of associations between gut bacteria with lean mass or with specific measures of physical function have yet to be reported. Accordingly, the over-arching hypothesis is that gut bacteria are associated with, and are causatively involved in mechanisms that underlie the maintenance of lean mass and physical function in older adults. Results obtained from the proposed study are intended as the basis for future studies aimed at targeted modulation of the gut microflora, which may be a novel and innovative means for improving lean mass and physical function, and for addressing the public health priority of healthy aging in older adults.