At a glance
ClinicalIndex Comparison Record- ✓Moderate to severe obstructive sleep apnea with AHI or RDI >10
- ✓Currently owns a CPAP machine and able to tolerate CPAP use
- ✕Uncontrolled hypertension: systolic BP >170 or diastolic BP >110 mmHg
- ✕Congestive heart failure
- ✕Current use of clonidine or nicotinic acid
- ✕Insulin-dependent diabetes mellitus
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Metabolic Impact of Intermittent CPAP
In Brief
A clinical study evaluating CPAP withdrawal for Obstructive Sleep Apnea. Completed, enrolled 144 participants across 1 site.
Detailed Summary
Obstructive sleep apnea is a risk factor for diabetes and cardiovascular disease, by unknown mechanisms. The investigators hypothesize that sleep apnea changes glucose and lipid metabolism during sleep, which over time could lead to diabetes and cardiovascular disease. This study examines metabolic changes during sleep in patients with obstructive sleep apnea. Patients accustomed to continuous positive airway pressure (CPAP) therapy are enrolled to undergo sleep studies, either on CPAP therapy or after withdrawing from CPAP for 3 nights. During sleep, blood samples are obtained so that metabolic function can be compared between sleep apnea and CPAP nights.
Study Details
Timeline
Interventions
CPAP is discontinued for 3 nights.