At a glance
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Topical Nitroglycerine Treatment for Radial Artery Spasm Prevention
In Brief
A Phase 4 clinical trial evaluating Topical Nitroglycerine and Topical Lidocaine for Radial Artery Spasm and 2 related conditions. Completed, enrolled 100 participants across 1 site.
Detailed Summary
The primary objective of the study is to determine the role of transdermal vasodilators as an adjunct to parenteral vasodilators in reducing radial artery spasm, improving patient comfort, and post procedure radial artery patency during transradial coronary angiograms and interventions. The study hypothesis is that transdermal vasodilators will increase radial artery size and reduce radial artery spasm as well as improve patient comfort and post procedure radial artery patency. This is a single-center, double-blind, randomized, placebo-controlled study comparing the effect of transdermal preparations of lidocaine + nitroglycerine and lidocaine + placebo on radial artery spasm in patients undergoing transdermal coronary angiograms. Prior to the procedure, each patient will be randomized into either the control arm, lidocaine + placebo, or study arm, lidocaine + nitroglycerine.
Study Details
Timeline
Interventions
Topical nitroglycerine is applied to wrist prior to transradial cardiac catheterization to dilate radial artery and reduce spasm in study arm patients
Topical Lidocaine is applied to wrist prior to transradial cardiac catheterization in both study and control arms