At a glance
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Improving Pulmonary Function Following Radiation Therapy
In Brief
A clinical study evaluating Laboratory Biomarker Analysis, Standard fractionation, and 2 other interventions for Non-Small Cell Lung Cancer. Completed, enrolled 122 participants across 2 sites.
Detailed Summary
The purpose of this study is to develop radiation plans that will help preserve lung function in healthy tissue surrounding the tumor. We believe that 4DCT scans can be useful in designing radiation treatment plans that help us avoid healthy normal functioning lung tissue close to lung tumors. Currently 4DCT scans are used to help us determine exactly where the tumor is and how it moves when you breathe. In this study we will also use the 4DCT scans to try to identify high functioning normal lung tissue.
Study Details
Timeline
Interventions
Correlative studies
60-66y Gy delivered in 1.8-2.0 Gy fractions over 30-36 treatments
40-60 Gy delivered in 5-20 Gy fractions over 3-8 treatments
Subjects undergo a total of 7 research-ordered four dimensional computed tomographic imaging (4DCT) scans: 1 at simulation, and 2 scans at each of the 3 post-radiation therapy time points (3, 6, and 12 months). 4DCT determines lung tissue elasticity and for standard of care radiation treatment planning.