At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Effect of Neuromuscular Blockade and Reversal by Sugammadex Versus Neostigmine on Breathing When Hypoxic or Hypercapnic in Volunteers
In Brief
A Phase 4 clinical trial evaluating Sugammadex, Neostigmine, and 1 other intervention for Respiratory Insufficiency. Completed, enrolled 46 participants across 1 site.
Detailed Summary
In this study the investigators will assess (i) the effect of partial neuromuscular blockade (NMB; TOF ratio 0.8 and 0.6) induced by low-dose rocuronium on the ventilatory response to isocapnic hypoxia and (ii) the effect over time (from TOF 0.6 to TOF 1.0) of the reversal by sugammadex, neostigmine or placebo in healthy volunteers. Additionally the investigators will assess the effect of partial NMB (TOF ratio 0.6) induced by low-dose rocuronium on the ventilatory response to hypercapnia and effect over time (from TOF 0.6 to TOF 1.0) of the reversal by sugammadex, neostigmine or placebo in healthy volunteers.
Study Details
Timeline
Interventions
Sugammadex will be administered following a period of muscle relaxation after wich respiratory measurements will be obtained.
Neostigmine will be administered following a period of muscle relaxation after wich respiratory measurements will be obtained.
Placebo will be administered following a period of muscle relaxation after wich respiratory measurements will be obtained.