CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 30 enrolled
Drug / intervention
Digoxin +7 moredrug
Likely dose
Digoxin 0.25 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02854527
NCT02854527Phase 1Completed
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Investigation of Mutual Pharmacokinetic Interactions of Digoxin, Furosemide, Metformin, and Rosuvastatin Given All Together as a Probe Cocktail for Key Drug Transporters (an Open-label, Randomised, Single-dose, Five-way Crossover Study)

Boehringer Ingelheim·interventional·Posted Aug 3, 2016·Updated Nov 7, 2023

In Brief

A Phase 1 clinical trial evaluating Digoxin, Furosemide, and 3 other interventions for Healthy. Completed, enrolled 30 participants across 1 site.

Detailed Summary

Main objective is to investigate mutual pharmacokinetic drug-drug interactions of digoxin, furosemide, metformin, and rosuvastatin when given all together as a cocktail

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHealthy
CountriesGermany
Collaborators--

Timeline

Phase 1CompletedFinished
2017201820192020202120222023202420252026
First PostedAug 3, 2016
Enrollment StartAug 22, 2016
Primary CompletionNov 11, 2016
Study CompletionNov 19, 2016
TodayJul 2, 2026
Enrollment to primary: 3 monthsPosted 9.9 years ago

Interventions

Digoxindrug

single dose

Furosemidedrug

single dose

Metformindrug

single dose

Rosuvastatindrug

single dose

Digoxindrug

0.25 mg digoxin as single dose (all 4 drugs given together as a cocktail at the same time point)

Furosemidedrug

1 mg furosemide as single dose (all 4 drugs given together as a cocktail at the same time point)

Metformin hydrochloridedrug

10 mg metformin hydrochloride as single dose (all 4 drugs given together as a cocktail at the same time point)

Rosuvastatindrug

10 mg rosuvastatin as single dose (all 4 drugs given together as a cocktail at the same time point)