CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 104 enrolled
Drug / intervention
Selonsertib +2 moredrug
Likely dose
Selonsertib 18 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02854631
NCT02854631Phase 2Completed

A Phase 2, Double-Blind, Randomized Study Evaluating the Safety, Tolerability, and Efficacy of GS-4997 in Combination With Prednisolone Versus Prednisolone Alone in Subjects With Severe Alcoholic Hepatitis (AH)

Gilead Sciences·interventional·Posted Aug 3, 2016·Updated Feb 6, 2019

In Brief

A Phase 2 clinical trial evaluating Selonsertib, Prednisolone, and 1 other intervention for Alcoholic Hepatitis (AH). Completed, enrolled 104 participants across 44 sites in 7 countries.

Detailed Summary

The primary objective of this study is to evaluate the safety and tolerability of selonsertib (GS-4997) in combination with prednisolone versus prednisolone alone in participants with severe alcoholic hepatitis (AH).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesAustria, Belgium, Canada, France, Switzerland, United Kingdom, United States
Collaborators--

Timeline

Phase 2CompletedFinished
2017201820192020202120222023202420252026
First PostedAug 3, 2016
Enrollment StartSep 1, 2016
Primary CompletionFeb 16, 2018
Study CompletionMay 31, 2018
TodayJul 2, 2026
Enrollment to primary: 1.5 yearsPosted 9.9 years ago

Interventions

Selonsertibdrug

18 mg tablet administered orally once daily

Prednisolonedrug

40 mg (4 x 10 mg tablets) administered orally once daily

Placebodrug

Selonsertib placebo tablet administered orally once daily