At a glance
ClinicalIndex Comparison Record- ✓Demonstrates understanding of study procedures and provides voluntary written informed consent
- ✓Good general and mental health with no clinically significant abnormalities in medical history or oral examination
- ✓Plaque sample acidogenicity in the pH range 5.0 to 5.7
- ✕Pregnant, intending to become pregnant, or breast-feeding
- ✕Currently taking or have taken antibiotics within 2 weeks of plaque assessment
- ✕Medical history that may prevent participation, such as diabetes
- ✕Grossly carious lesions (active), moderate or severe periodontal conditions, or severe tooth wear
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Study to Investigate the Antimicrobial Activity of Two Test Toothpastes in a Plaque Glycolysis and Regrowth Model
In Brief
A clinical study evaluating Test zinc-IPMP toothpaste, Test zinc non- IPMP toothpaste, and 3 other interventions for Dental Plaque. Completed, enrolled 45 participants across 1 site.
Detailed Summary
The aim of this exploratory study is to assess the ability of two test toothpastes containing 0.6% w/w zinc chloride stabilised with sodium citrate in a sodium lauryl sulfate (SLS)-containing base to reduce glycolytic metabolism and viability of de novo plaque bacteria using the plaque glycolysis regrowth model (PGRM).
Study Details
Timeline
Interventions
Test toothpaste containing 0.6% w/w zinc chloride and 0.1% w/w IPMP and 1426ppm fluoride as sodium fluoride.
Test toothpaste containing 0.6% w/w zinc chloride, 0% w/w IPMP and 1426ppm fluoride as sodium fluoride.
Positive control toothpaste containing 0.454% w/w stannous fluoride (Fluoride Toothpaste (1100ppm Fluoride as stannous fluoride)).
Negative control toothpaste containing 2.0% SLS, 0.65% Tegobetain and 1150 ppm fluoride as sodium fluoride
Negative control toothpaste containing 1426 ppm fluoride as sodium fluoride