At a glance
ClinicalIndex Comparison Record- ✓Term or preterm infants ≥28 weeks' gestation
- ✓Requiring chest compressions in the delivery room
- ✕Congenital abnormality or condition adversely affecting breathing or ventilation (e.g., congenital diaphragmatic hernia)
- ✕Congenital heart disease requiring intervention in the neonatal period
- ✕Parental refusal of consent
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
SURV1VE-Trial - Sustained Inflation and Chest Compression Versus 3:1 Chest Compression to Ventilation Ratio During Cardiopulmonary Resuscitation of Asphyxiated Newborns: A Randomized Controlled Trial
In Brief
A clinical study evaluating CC+SI and 3:1 C:V for Heart Arrest and 2 related conditions. Completed, enrolled 27 participants across 4 sites in 2 countries.
Detailed Summary
Research question In newborn infants requiring CPR, does CC superimposed by sustained inflation compared to 3:1 compression to ventilation ratio improves return of spontaneous circulation? Overall objective: CC superimposed by sustained inflation will improve short- and long-term outcomes in preterm (\>28 weeks or older) and term newborns. Hypothesis to be tested Primary hypothesis: By using CC superimposed by sustained inflation (CC+SI) during CPR the time needed to achieve return of spontaneous circulation (ROSC) compared to the current 3:1 compression to ventilation (C:V) will be reduced in asphyxiated newborns.
Study Details
Timeline
Interventions
chest compression will be delivered during sustained inflation (CC+SI). The duration of each sustain inflation is 20sec. After 20sec a pause of 1sec id done before the next sustained inflation is delivered for another 20sec. Chest compressions are given continuously. This approach is continued until return of spontaneous circulation.
During 3:1 C:V. 3 chest compressions are given, then stopped and then 1 inflation is given. This approach is continued until return of spontaneous circulation.