At a glance
ClinicalIndex Comparison Record- ✓Antepartum women with diagnosis of Gestational Hypertension or Pre-eclampsia confirmed by blood pressure ≥140 systolic or ≥90 diastolic on at least 2 measurements ≥4 hours apart; with or without proteinuria
- ✓Taking 1 or fewer oral medications for blood pressure control
- ✓Singleton gestation
- ✓English-speaking
- ✕Allergy to nonsteroidal anti-inflammatory drugs, aspirin, or acetaminophen
- ✕More than 1 severe range blood pressure (≥160 systolic or ≥110 diastolic) prior to enrollment
- ✕Neurologic symptoms attributed to hypertension (headache, visual changes) prior to enrollment
- ✕Pulmonary edema
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Randomized-controlled Trial to Assess the Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy
In Brief
A Phase 4 clinical trial evaluating Ibuprofen and Acetaminophen for Hypertension, Pregnancy-Induced and Pre-eclampsia. Completed, enrolled 74 participants across 1 site.
Detailed Summary
To assess the effect of routine doses of ibuprofen on post-partum blood pressure control in women with gestational hypertension (gHTN) or preeclampsia without severe features (preE).
Study Details
Timeline
Interventions
At the time of delivery, eligibility will be reviewed. If the participant remains eligible, she will be randomized by the study pharmacy to begin post-partum analgesic therapy with ibuprofen followed by acetaminophen.
At the time of delivery, eligibility will be reviewed. If the participant remains eligible, she will be randomized by the study pharmacy to begin post-partum analgesic therapy with acetaminophen followed by ibuprofen.