At a glance
ClinicalIndex Comparison Record- ✓Age between 18 and 85 years old
- ✓Undergoing total knee or hip replacement surgery
- ✓Fluent in English, decision competent, willing and able to provide written informed consent
- ✓Able to walk more than 3 meters without an assisting device
- ✕Currently participating in another orthopedic, physical therapy, rehab, or anesthesiology interventional clinical trial
- ✕Significant behavioral risks or refractory major psychiatric disorders
- ✕Revision surgery on the same extremity
- ✕ASA Physical Status classification 4 or higher
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
4-drug Nerve Block Versus Plain Local Anesthetic for Knee and Hip Arthroplasty Analgesia in Veterans
In Brief
A Phase 3 clinical trial evaluating Bupivacaine + CBD (clonidine, buprenorphine, dexamethasone) and Bupivacaine Only (control arm) for Pain. Completed, enrolled 98 participants across 1 site.
Detailed Summary
After total joint replacement, early hospital discharge to home (with patients capable of continuing a home-based rehabilitation program) is a cost- effective management strategy. This project will use improved local anesthetic nerve block techniques to enhance technical capability and clinical practice by (i) reducing pain and other morbidities during recovery, (ii) improving weight-bearing achievement during in-hospital physical therapy to allow for earlier return home, and (iii) continued rehabilitation as an outpatient at home when feasible (versus in an extended care facility).
Study Details
Timeline
Interventions
Nerve blocks before surgery of L2-L4 and L4-S3 for Knee replacements Nerve blocks before surgery of L2-L4 for hip replacements
Nerve blocks before surgery of L2-L4 and L4-S3 for Knee replacements Nerve blocks before surgery of L2-L4 for hip replacements