At a glance
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Pathogenesis of Acute Stress Induced (Tako-tsubo) Cardiomyopathy: Energy Shut-Down or Intense Inflammation? The TERRIFIC Study
In Brief
An observational study evaluating Magnetic resonance imaging, Acute Inflammatory Activation study, and 2 other interventions for Tako-tsubo Cardiomyopathy. Completed, enrolled 77 participants across 1 site.
Detailed Summary
Tako Tsubo Cardiomyopathy (TTC), also known as "Broken Heart Syndrome", is a disorder of the heart that occurs most commonly in women (although it occasionally occurs in men) and is usually related to a stressful event. Symptoms are often similar to a heart attack, and include chest pain and shortness of breath. Although Tako Tsubo Cardiomyopathy is not a new medical condition, it has not been widely recognised until the last decade. Currently the investigators don't have an exact understanding of how or why the heart is affected in this way, and so the investigators are conducting a study to help understand what causes Tako Tsubo Cardiomyopathy.
Study Details
Timeline
Interventions
Cardiac MRI and short MRI following USPIO infusion
Blood sampling for exploration of type and level of inflammatory response
PET study for metabolic pathway study
Assessment by a psychologist