At a glance
ClinicalIndex Comparison Record- ✓Age 18–70 years
- ✓Planned hip or knee arthroplasty with spinal anesthesia
- ✓Ability to provide informed consent
- ✕History of or current hepatic or renal insufficiency
- ✕BMI ≥33
- ✕Heart failure or active arrhythmias
- ✕Severe systemic disease that is a constant threat to life
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Investigation of Cerebrospinal Fluid (CSF) Pharmacokinetics of Ondansetron
In Brief
A clinical study evaluating Ondansetron for Pain. Completed, enrolled 19 participants across 1 site.
Detailed Summary
Serotonergic 5-HT3 receptors in the central nervous system are involved in pain processing after nerve injury. We are interested in learning if 5-HT3 receptor antagonist ondansetron might be an appropriate drug for treating pain after nerve injury (neuropathic pain), by investigating its bio-distribution in the cerebro-spinal fluid, and the genetic variability that may affect that distribution. Study procedures will include iv ondansetron administration, serial blood draws, cerebrospinal fluid (CSF) sampling, pregnancy testing, and possible ECG.
Study Details
Timeline
Interventions
A single 15-min intravenous infusion of ondansetron