At a glance
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Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest (TTM2) - A Randomised Clinical Trial
In Brief
A clinical study evaluating Targeted temperature management to 33°C and Standard care with early treatment of fever for Out-of-hospital Cardiac Arrest. Completed, enrolled 1,900 participants across 60 sites in 14 countries.
Detailed Summary
ILCOR guidelines recommend Target Temperature Management (TTM) to between 32°C and 36°C after out-of-hospital cardiac arrest, based on low quality evidence. In a previous trial, TTM at 33°C did not confer a survival benefit or improved neurological function, compared to TTM at 36°C. A lower target temperature might be beneficial compared with normothermia and early treatment of fever. Therefore the primary purpose of the TTM2-trial will be to study any differences in mortality, neurological function and quality of life between a target temperature of 33°C and standard care avoiding fever.
Study Details
Timeline
Interventions
Rapid cooling to below 33°C, followed by temperature control at 33°C for up to 28h.
Normothermia and standard care - use of a device for temperature control if temperature is greater than or equal to 37.8°C