At a glance
ClinicalIndex Comparison Record- ✓Diagnosis of severe hypertensive disorder of pregnancy: preeclampsia with severe features, HELLP syndrome, eclampsia, or chronic hypertension with superimposed preeclampsia with severe features
- ✓Not yet delivered or less than 6 hours after delivery at enrollment
- ✓Ability to give informed consent
- ✕Serum creatinine >1.0 mg/dL or suspicion of acute kidney injury
- ✕AST >200 unit/L or ALT >200 unit/L
- ✕Known allergy or sensitivity to NSAIDs or acetaminophen
- ✕Chronic kidney disease, chronic liver disease, prior liver transplant, or chronic infectious hepatitis
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features
In Brief
A Phase 4 clinical trial evaluating Acetaminophen and Ibuprofen for Pre-Eclampsia and 2 related conditions. Completed, enrolled 100 participants across 1 site.
Detailed Summary
NSAIDs, specifically cyclo-oxygenase (COX) inhibitors, are known to increase blood pressure over time in non-pregnant adults, but the effect of COX-inhibitors on blood pressure in the setting of preeclampsia have not been well studied. This study aims to assess the effect of avoiding COX-inhibitors on postpartum blood pressure control among women diagnosed with preeclampsia with severe features. Eligible women will be randomized to receive either acetaminophen or ibuprofen for postpartum pain control. Both agents are first line therapies for pain control although ibuprofen has better pain control than acetaminophen. The primary outcome will be duration of postpartum severe-range hypertension.