CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 62 enrolled
Drug / intervention
Risdiplamdrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT02913482
NCT02913482Phase 2Completed

A Two Part Seamless, Open-label, Multicenter Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of Risdiplam (RO7034067) in Infants With Type 1 Spinal Muscular Atrophy

Hoffmann-La Roche·interventional·Posted Sep 23, 2016·Updated Aug 7, 2024

In Brief

A Phase 2 clinical trial evaluating Risdiplam for Muscular Atrophy, Spinal. Completed, enrolled 62 participants across 32 sites in 16 countries.

Detailed Summary

Open-label, multi-center clinical study is to assess the safety, tolerability, pharmacokinetic (PK), pharmacodynamics (PD), and efficacy of Risdiplam (RO7034067) in infants with Type 1 spinal muscular atrophy (SMA). The study consists of two parts, an exploratory dose finding part (Part 1) and a confirmatory part (Part 2) which will investigate Risdiplam (RO7034067) for 24-months at the dose selected in Part 1.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesBelgium, Brazil, China, Croatia, France, Italy, Japan, Poland, Russia, Saudi Arabia, Serbia, Spain, Switzerland, Turkey (Türkiye), Ukraine, United States
Collaborators--

Timeline

Phase 2CompletedFinished
2017201820192020202120222023202420252026
First PostedSep 23, 2016
Enrollment StartDec 23, 2016
Primary CompletionNov 14, 2019
Study CompletionDec 22, 2023
TodayJul 2, 2026
Enrollment to primary: 2.9 yearsPosted 9.8 years ago

Interventions

Risdiplamdrug

Risdiplam will be administered orally.