At a glance
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Platelet Function in Resuscitated Patients
In Brief
An observational study evaluating diagnostic analysis of platelet function for Acute ST Segment Elevation Myocardial Infarction. Completed, enrolled 99 participants across 1 site.
Detailed Summary
Approx. 65% of resuscitated patients at the intensive care unit for internal medicine are due to myocardial infarction. Almost all patients are initially diagnosed and treated in the cath lab. Therapy usually consists of one or more stent implantations. After implantation of a coronary stent, dual platelet inhibition is necessary for 12 months. Insufficient platelet inhibition causes an pronounced increase in risk of stent thrombosis. Therefore, knowledge of the individual platelet function is valuable. Several factors potentially promote a delayed or reduced mode of action of platelet function inhibitors in resuscitated patients: 1. oral administration is impossible and medication needs to be administered via a gastric line. 2. gastric absorption is delayed after resuscitation 3. according to current guidelines patients are treated with therapeutic hypothermia. Including the time of rewarming cooling period is \~48h
Study Details
Timeline
Interventions
analysis of platelet aggregation using optical measurements as well as the commercial VerifyNow technique