At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Multi Ethnic Study of Atherosclerosis Individualized Response to Vitamin D Treatment Study
In Brief
A clinical study evaluating Vitamin D3 and Placebo for Characteristics That Modify the Response to Cholecalciferol Treatment. Completed, enrolled 666 participants across 5 sites.
Detailed Summary
The goal of this clinical trial is to determine individual-level genetic and metabolic characteristics that modify the response to cholecalciferol treatment. This study is double blind, parallel design, randomized clinical trial that will assess genetic and metabolic characteristics that modify the response to cholecalciferol treatment. . Eligible participants will be randomly assigned to receive cholecalciferol treatment (2,000 international units of cholecalciferol daily by mouth) or placebo in a 3:1 ratio for a total duration of 16-weeks. The planned sample size is 1,600. The primary aim of this study is to identify genetic polymorphisms, clinical characteristics, and biomarkers that modify the biologic response to vitamin D3 treatment, assessed by changes in serum concentrations of parathyroid hormone (PTH) and 1,25(OH)2D and urine calcium excretion.
Study Details
Timeline
Interventions
cholecalciferol (vitamin D3) 2000 IU capsules daily