At a glance
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The Role of Oral Steroids in the Management of Chronic Rhinosinusitis Without Nasal Polyps
In Brief
A clinical study evaluating 6 day Prednisone, Augmentin, and 1 other intervention for Sinusitis. Completed, enrolled 24 participants across 1 site.
Detailed Summary
Chronic rhinosinusitis is a common disease that effects millions of people world wide. Despite its frequency it is unclear what treatment options are the best for these patients. Typically patients with chronic rhinosinusitis without nasal polyps (CRSsNP) are given a long term antibiotic (3 weeks), nasal steroid sprays, saline nasal irrigation and occasionally oral steroids. Oral steroids benefit patients with chronic rhinosinusitis with nasal polyps (CRSwNP) however their role in non polyp patients is less clear. It is the goal of this study to see if oral steroids benefit the treatment outcomes in those patients with chronic rhinosinusitis without nasal polyps. In addition this study will look to see if a short course (5 day burst) versus a longer course (21 day taper) of oral steroids make a difference in outcomes.
Study Details
Timeline
Interventions
6 day prednisone burst
Antibiotic augmentin for 3 weeks
21 day prednisone burst