At a glance
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Investigating the Stability, Variability and Mechanism of Incorporation of Lipid Mediators Into Eccrine Sweat
In Brief
A clinical study evaluating Ibuprofen, Physiological induction of sweating, and 1 other intervention for Stability & Variability of Lipid-derived Molecules in Sweat. Completed, enrolled 14 participants across 1 site.
Detailed Summary
The purpose of this study is to see what the differences are in sweat (amount and small molecule content) collected from different sites of the body and by different methods of sweat stimulation. Additionally, the investigators want to know whether the amount and small molecule content of the sweat is the same in an individual over time, and the same across individuals at a given time. Finally, the investigators want to know how consumption of over-the-counter anti-inflammatory drugs such as ibuprofen will affect the inflammatory mediator content of sweat and how that compares to blood. This information will help to better understand the composition and behavior of sweat and assess its potential utility as a routine clinical tool in skin research.
Study Details
Timeline
Interventions
400 mg ibuprofen given to inhibit cyclooxygenase metabolism
15 minutes exercise at 60-80% oxygen consumption to induce sweating
Iontophoresis with a 1.5 milliampere (mA) current using a gel disc containing a 5% pilocarpine nitrate solution to induce sweating