CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 156 enrolled
Drug / intervention
Health and Wellness Combined Cognitive Behavioral Therapy and a Medication Management Algorithm +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

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NCT02939131N/ACompleted
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IMPAACT 2002: Combined Cognitive Behavioral Therapy and a Medication Management Algorithm for Treatment of Depression Among Youth Living With HIV in the United States

International Maternal Pediatric Adolescent AIDS Clinical Trials Group·interventional·Posted Oct 19, 2016·Updated Mar 3, 2021

In Brief

A clinical study evaluating Health and Wellness Combined Cognitive Behavioral Therapy and a Medication Management Algorithm and Enhanced Standard of Care for HIV and Depression. Completed, enrolled 156 participants across 13 sites.

Detailed Summary

IMPAACT 2002 is a prospective, multi-site, two-arm, cluster-randomized study to evaluate whether a health and wellness Cognitive Behavioral Therapy and Medication Management (COMB-R) intervention for depression demonstrates improved depression and medical outcomes for HIV-infected youth in the United States (US) compared to enhanced standard care (ESC).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHIV, Depression
CountriesUnited States
CollaboratorsNational Institute of Allergy and Infectious Diseases (NIAID), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute of Mental Health (NIMH)

Timeline

N/ACompletedFinished
2017201820192020202120222023202420252026
First PostedOct 19, 2016
Enrollment StartMar 6, 2017
Primary CompletionSep 12, 2019
Study CompletionJan 21, 2020
TodayJul 2, 2026
Enrollment to primary: 2.5 yearsPosted 9.7 years ago

Interventions

Health and Wellness Combined Cognitive Behavioral Therapy and a Medication Management Algorithmbehavioral

Behavioral therapy based on a manualized approach developed specifically for youth living with both HIV and depression, using problem-solving, motivational interviewing and cognitive-behavioral strategies to decrease adherence obstacles and increase wellness. The medication management algorithm includes guidance for clinicians on strategies and tactics to treat depression in this population, including factors to consider when deciding on treatments (i.e., drug-drug interactions, side effects).

Enhanced Standard of Carebehavioral

Ongoing psychopharmacological and psychosocial counseling and treatment for depression at HIV clinical treatment centers enhanced by providing clinicians with up-to-date information and didactic training on current principles for use of medication and psychotherapy in the treatment of depression.