At a glance
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Vaping THC From Electronic Cigarettes: a Novel Evaluation of Intake and Pharmacokinetics
In Brief
A Phase 3 clinical trial evaluating Nicotine, Cannabis, and 1 other intervention for Marijuana Dependence. Completed, enrolled 8 participants across 1 site.
Detailed Summary
This study aims to understand THC pharmacology and the safety of cannabis vaping, including the pharmacology and safety of co-administration of nicotine and THC. The study is designed as a within-subjects single-blinded crossover study. Fourteen smokers of tobacco cigarettes and cannabis will switch between three conditions, namely: (a) vaping cannabis leaf, (b) vaping tobacco containing nicotine and (c) vaping a combination of cannabis leaf and tobacco containing nicotine. All participants will vape each product with the PAX loose-leaf vaporizer. The study will be conducted during three outpatient visits separated by at least 48 hours. The order of treatment (cannabis leaf, tobacco with nicotine, cannabis leaf \& tobacco with nicotine) will be counterbalanced between subjects. Subjects will be blinded to the content of the vaporizer on the study day but will be told during screening that they will vape cannabis alone, tobacco alone, and cannabis plus tobacco with nicotine.
Study Details
Timeline
Interventions
Participants will vape tobacco leaves with nicotine out of the PAX device.
Participants will vape marijuana leaves with nicotine out of the PAX device.
In all three arms, the participant will be using the same PAX electronic cigarette device. The only difference is whether the participant will be vaping nicotine only, THC only, or nicotine and THC.