At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Acute Insulin Effects on Cardiac Function in Patients With Diabetes Mellitus
In Brief
A Phase 4 clinical trial evaluating Insulin LISPRO intravenous loading for Diabetes Mellitus and Ventricular Dysfunction. Completed, enrolled 6 participants across 1 site.
Detailed Summary
Our investigation studies the role of acute insulin administration on the diabetic heart, its corresponding effective blood-insulin level and the time-course applicability of insulin in a routine clinical setting. A case series of six male (48.1 ± 4.9 y/o) patients with controlled diabetes (HbA1c of 6.6 ± 0.3%, disease duration of 14.4 ± 6.7 yr). Each subject was evaluated for glucose homeostatic, hemodynamic and echocardiographic systolic and diastolic parameters at baseline and following two successive insulin-load steps of a euglycemic hyperinsulinemic clamp study, each 2 h in duration. Results are presented as a mean ± SEM and analysed using the student's t-test.
Study Details
Timeline
Interventions
intravenous infusion of insulin Lispro.